Cannabis Therapeutics and the Future of Neurology.
Dr. Russo reports that based on the studies published so far, there is proven effect of phytocannabinoids on spasticity of Multiple Sclerosis, epilepsy (Dravet and Lennox-Gastaut syndromes), chronic pain and schizophrenia.
Promising data from studies so far, but without undeniable results yet, appear in symptoms such as sleep disorders (as a symptom of neurological diseases), glaucoma, Tourette’s syndrome and lower urinary tract symptoms (as a symptom of MS).
He emphasizes that, especially in Alzheimer’s disease, combinations of phytocanabinoids (and in some cases terpenes) also help with the symptoms as shown below:
o Agitation: THC, CBD, linalool
o Anxiety: CBD, THC (low dose), linalool
o Psychosis: CBD
o Insomnia / anxiety: THC, linalool
o Anorexia: THC
o Aggressiveness: THC, CBD, linalool
o Depression: THC, limonene, CBD
o Pain: THC, CBD
o Memory: alpha-pinene (Russo, 2011, Russo and Marcu, 2017) + THC
o Neuroprotection: CBD, THC
o Reduced formation of amyloid plaques (Aβ): THC, CBD, THCA
To conclude, he proposes as prevention (and in some cases as a treatment) the following strategies:
- Aerobic exercise
- Education as a way of life (lifelong learning)
- Anti-inflammatory diet, high in probiotics and prebiotics, omega-3 fatty acids, bioflavonoids (fruits, mainly berries), protein, restriction of carbohydrate intake
- Supplement with cannabis extracts containing THC, CBD, THCA, CBDA, caryophyllene and other selected terpenoids.
Note: The comments above are an interpretation of a scientific publication. They are not medical advice. Before implementing any changes to your diet, medication or treatment, you must consult your doctor.
Source: Russo EB (2018) Cannabis Therapeutics and the Future of Neurology. Front. Integr. Neurosci. 12:51. two: 10.3389 / fnint.2018.00051
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