Dr. Russo reports that based on the studies published so far, there is proven effect of phytocannabinoids on spasticity of Multiple Sclerosis, epilepsy (Dravet and Lennox-Gastaut syndromes), chronic pain and schizophrenia.
Promising data from studies so far, but without undeniable results yet, appear in symptoms such as sleep disorders (as a symptom of neurological diseases), glaucoma, Tourette’s syndrome and lower urinary tract symptoms (as a symptom of MS).
He emphasizes that, especially in Alzheimer’s disease, combinations of phytocanabinoids (and in some cases terpenes) also help with the symptoms as shown below:
o Agitation: THC, CBD, linalool
o Anxiety: CBD, THC (low dose), linalool
o Psychosis: CBD
o Insomnia / anxiety: THC, linalool
o Anorexia: THC
o Aggressiveness: THC, CBD, linalool
o Depression: THC, limonene, CBD
o Pain: THC, CBD
o Memory: alpha-pinene (Russo, 2011, Russo and Marcu, 2017) + THC
o Neuroprotection: CBD, THC
o Reduced formation of amyloid plaques (Aβ): THC, CBD, THCA
To conclude, he proposes as prevention (and in some cases as a treatment) the following strategies:
- Aerobic exercise
- Education as a way of life (lifelong learning)
- Anti-inflammatory diet, high in probiotics and prebiotics, omega-3 fatty acids, bioflavonoids (fruits, mainly berries), protein, restriction of carbohydrate intake
- Supplement with cannabis extracts containing THC, CBD, THCA, CBDA, caryophyllene and other selected terpenoids.
Note: The comments above are an interpretation of a scientific publication. They are not medical advice. Before implementing any changes to your diet, medication or treatment, you must consult your doctor.
Source: Russo EB (2018) Cannabis Therapeutics and the Future of Neurology. Front. Integr. Neurosci. 12:51. two: 10.3389 / fnint.2018.00051
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